ODCs

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1 OMIM reference -
1 associated gene
13 signs/symptoms

PROTEIN INTERACTIONS: 1

1 OMIM reference -
1 associated gene
18 signs/symptoms

Intellectual deficit, X-linked - psychosis - macroorchidism

Hypotrichosis - lymphedema - telangiectasia


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	MECP2	(0.63)	SOX18

Citations in the biomedical literature:

Intellectual deficit, X-linked - psychosis - macroorchidism		Hypotrichosis - lymphedema - telangiectasia
	Synonym(s): - Lindsay-Burn syndrome - PPM-X		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease - Rare neurologic disease		Classification (Orphanet): - Rare circulatory system disease - Rare genetic disease - Rare skin disease

	Classification (ICD10): - Mental and behavioural disorders -		Classification (ICD10): (no data available)

	Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: childhood Average age of death: - Type of inheritance: x-linked dominant		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: no data available Type of inheritance: autosomal dominant

	External references: 1 OMIM reference - No MeSH references		External references: 1 OMIM reference - No MeSH references

Intellectual deficit, X-linked - psychosis - macroorchidism		Hypotrichosis - lymphedema - telangiectasia
	Very frequent - Hypertonia / spasticity / rigidity / stiffness - Intellectual deficit / mental / psychomotor retardation / learning disability - Macroorchidism / macrotestes - Movement disorder - Psychic / behavioural troubles - X-linked recessive inheritance Frequent - Abnormal gait - EEG anomalies - Long / large ear - Seizures / epilepsy / absences / spasms / status epilepticus Occasional - Psychic / psychomotor regression / dementia / intellectual decline - Scoliosis - Structural anomalies of the cardio-circulatory system		Very frequent - Absent / decreased / thin eyebrows - Alopecia - Decreased body hair / axillar / pubic hairlessness - Edema of the legs / lower limbs - Hypotrichosis / atrichia / atrichiasis / scalp hairlessness - Lymphangioma / lymphatic malformations - Lymphedema - Telangiectasiae of the skin Frequent - Anomalies of eyelids, eyelashes and lacrimal system - Cutis marmorata / marbled skin / livedo - Follicular / erythematous / edematous papules / milium - Palpebral edema / periorbital edema - Vaginal hydrocele / hematocele / pyocele / lymphocele / varicocele - Varices / varicous veins / venous insufficiency Occasional - Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax - Capillary hemangioma / nevus / naevus flammeus / port-wine stain - Hydrops fetalis - Structural anomaly of the peritoneum